TzymeTM Protease Blend in TPPTM Protease provides vital systemic benefits that include support of adequate blood rheology for optimum flow of immune cells, their meditating molecules, hormones, blood cells and other vital molecules and cells. The superb absorption abilities and high functionality of this product are certain to enhance and optimize overall protein hydrolysis. These benefits, in turn, facilitate and support a wide array of metabolic processes.
Bromelain, an important addition to the TzymeTM Protease Blend, is a protease derived from the pineapple plant. It has been used for many years as a digestive aid, anti-inflammatory and burn debridement agent. Its actions help to prevent swelling/edema, promote smooth muscle relaxation, inhibit platelet aggregation, and enhance antibiotic absorption. Bromelain is also used in cancer treatment, ulcer prevention, sinusitis relief, appetite inhibition and shortening of labor. Proteolytic enzymes administered orally improved the survival time, the hematological parameters of spontaneous lymphoblastic leukemia in rats, and the metastasis and survival time of mice with Lewis lung carcinoma.
Several hypotheses have been put forth as to the mechanisms by which proteolytic enzymes modulate the immune system to control and eliminate tumors. Some studies indicated that proteolytic enzymes selectively remove some adhesion molecules such as CD4, CD44, B7-1, ICAM-1, B7-2, CD45RA, CD6, CD7, E2/MIC2, and Leu81/LAM 1 from cell surfaces According to Hale et al. the removal of these surface molecules has markedly enhanced CD2 mediated T-cell activity.
Some studies have implied that by removing the glycoprotein CD44, some proteases help control the tumor growth of certain types of cells. This selective removal of some mediator proteins, and the regulation of cytokines constitute some factors by which proteolytic enzymes are thought to modulate the immune system and act as biological response modifiers."