Tissue repair or wound healing is usually divided into three phases. The inflammatory phase is charecterized by platelet accumulation, coagulation and leukocyte migration. The proliferate phase involves re-epithelialization, angiogenesis, fibroplasia and wound contraction. The remodeling phase takes place over a period of months. During this stage of tissue repair, the dermis responds to injury with the production of collagen and matrix proteins and then returns to its pre-injury structure. Research has shown that these processes are regulated by various cytokines. Oral protease supplementation leads to the formation of activated a2M, which significantly modulates tissue cytokines.
TzymeTM is the trademark of a proprietary blend of highly active, functional enzymes. These enzymes are pH balanced and GI tract stable. This blend is formulated to enhance the digestive process and impart systemic benefits.
Studies have indicated that oral hydrolytic enzymes affect cytokine synthesis and modulatory effects. For instance, TNF-a synthesis, which is a necessary step in host defense against tumor cells, was impaired when experimentally inactivated oral proteolytic enzymes were used. Thus, active, gastrointestinal stable and functional oral enzymes that are absorbed in the blood stream can provide therapeutic applications. In addition, studies have shown that oral proteolytic enzymes increased the tumoricidal and cytotoxic activities of polymorphonuclear neutrophils. Bromelain, a protease derived from the pineapple plant, has been used for many years as a digestive aid, burn debridement agent and anti-inflammatory agent. Its actions help to prevent swelling/edema, promote smooth muscle relaxation, inhibit platelet aggregation and enhance antibiotic absorption. Bromelain is also used in ulcer prevention, sinusitis relief, cancer treatment, appetite inhibition and shortening of labor.
TzymeTM Anti-Ox Blend - This comprehensive blend of antioxidant ingredients scavenges and corrects molecules damaged by free radicals, thus helping to prevent a free radical domino effect within the body. The natural minerals, bioflavonoids, herbs and vitamins in this unique formulation are designed to help the body control inflammation and enhance the healing process.
Rutin, a bioflavonoid, has been demonstrated to be a potent anti-inflammatory agent in recent studies, in part due to inhibiting phospholipase A2.
Quercetin, a bioflavonoid, has been shown to modify eicosanoid biosynthesis (antiprostanoid and anti-inflammatory responses). It has been found to inhibit membrane lipid peroxidation. Quercetin has potent anticarcinogenic, antioxidative and anti-inflammatory properties.
Grape Seed Extract contains concentrated procyanidolic oligomers (PCO), which are mixtures of dimers, trimers, and larger polymers of proanthocyanidins. The PCOs scavenge free radicals and inhibit decarboxylase in the inflammatory process, thereby reducing inflammation. PCO's are among the best-studied and most effective bioflavonoids, based in part on their powerful antioxidant activity.
Kelp and Irish Moss are rich sources of a wide variety of minerals, including potassium, sodium, calcium, chlorine, copper, iron, iodine, selenium, zinc, bromine and manganese. One consequence of inflammation is a sizable loss of body nitrogen, potassium, magnesium, phosphate, and zinc and the subsequent retention of body salt and water.
TPPTM Protease Blend - This proprietary blend of enzymes consists of alkaline, neutral, and acid proteases, exo/endo peptidase, bromelain and papain. These enzymes are active in a wide range of pH's, ensuring that proper protein digestion will initiate in the stomach. The addition of the endo-and exo-peptidase in this product, which provides a wider range of specificities, ensures the highest degree of protein hydrolysis."